A new class of alkaloids from a dendrobatid poison frog: a structure for alkaloid 251F

J Nat Prod. 1992 Jun;55(6):707-22. doi: 10.1021/np50084a002.

Abstract

Alkaloids of a new class are present in skin extracts of the dendrobatid poison frog, Minyobates bombetes, of Colombia. The structure of the major alkaloid of this class, 251F, has been determined as a trimethylcyclopenta[b]quinolizidinemethanol 1 by nmr, gc-Ft-ir, and ms studies including ms-ms. At least nine congeners of 251F were detected in these extracts.

MeSH terms

  • Alkaloids / analysis*
  • Alkaloids / chemistry
  • Animals
  • Anura / metabolism*
  • Colombia
  • Mass Spectrometry
  • Skin / chemistry

Substances

  • Alkaloids