In vitro activity of protegrin-1 and beta-defensin-1, alone and in combination with isoniazid, against Mycobacterium tuberculosis

Lanfranco Fattorini; Renato Gennaro; Margherita Zanetti; Dejiang Tan; Lara Brunori; Federico Giannoni; Manuela Pardini; Graziella Orefici

doi:10.1016/j.peptides.2004.04.003

In vitro activity of protegrin-1 and beta-defensin-1, alone and in combination with isoniazid, against Mycobacterium tuberculosis

Peptides. 2004 Jul;25(7):1075-7. doi: 10.1016/j.peptides.2004.04.003.

Authors

Lanfranco Fattorini¹, Renato Gennaro, Margherita Zanetti, Dejiang Tan, Lara Brunori, Federico Giannoni, Manuela Pardini, Graziella Orefici

Affiliation

¹ Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Rome, Italy.

PMID: 15245864
DOI: 10.1016/j.peptides.2004.04.003

Abstract

The antimicrobial peptide protegrin-1 (PG-1) inhibited the growth in vitro of drug-susceptible and multidrug-resistant Mycobacterium tuberculosis; a lower activity was shown by human beta-defensin-1 (HBD-1) against both strains. The combination of PG-1 or HBD-1 with isoniazid significantly reduced M. tuberculosis growth in comparison with the peptides or isoniazid alone.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / pharmacology*
Antimicrobial Cationic Peptides
Drug Synergism
Humans
Isoniazid / pharmacology*
Mycobacterium tuberculosis / drug effects*
Mycobacterium tuberculosis / growth & development
Proteins / isolation & purification
Proteins / pharmacology*
beta-Defensins / pharmacology*

Substances

Anti-Infective Agents
Antimicrobial Cationic Peptides
DEFB1 protein, human
Proteins
beta-Defensins
protegrin-1
Isoniazid