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Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes.
J Biol Chem. 2004 Nov 5;279(45):46455-63. doi: 10.1074/jbc.M406289200. Epub 2004 Aug 17.
J Biol Chem. 2004.
PMID: 15322109
Free article.
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P.
Chen F, et al.
Nature. 2006 Apr 27;440(7088):1208-12. doi: 10.1038/nature04667.
Nature. 2006.
PMID: 16641999
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Cellular localization of Nicastrin affects amyloid beta species production.
Morais VA, Leight S, Pijak DS, Lee VM, Costa J.
Morais VA, et al.
FEBS Lett. 2008 Feb 6;582(3):427-33. doi: 10.1016/j.febslet.2008.01.003. Epub 2008 Jan 15.
FEBS Lett. 2008.
PMID: 18201567
Free article.
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Ferritin light chain interacts with PEN-2 and affects γ-secretase activity.
Li X, Liu Y, Zheng Q, Yao G, Cheng P, Bu G, Xu H, Zhang YW.
Li X, et al.
Neurosci Lett. 2013 Aug 26;548:90-4. doi: 10.1016/j.neulet.2013.05.018. Epub 2013 May 15.
Neurosci Lett. 2013.
PMID: 23685131
Free PMC article.
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Bax inhibitor 1 is a γ-secretase-independent presenilin-binding protein.
Wu S, Song W, Wong CCL, Shi Y.
Wu S, et al.
Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):141-147. doi: 10.1073/pnas.1810870116. Epub 2018 Dec 17.
Proc Natl Acad Sci U S A. 2019.
PMID: 30559186
Free PMC article.
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A reference map of the human binary protein interactome.
Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Coté AG, Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF, Kishore N, Knapp JJ, Kovács IA, Lemmens I, Mee MW, Mellor JC, Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A, Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG, Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S, Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A, Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S, Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli D, Sheynkman GM, Simonovsky E, Taşan M, Tejeda A, Tropepe V, Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X, Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S, Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP, Calderwood MA.
Luck K, et al.
Nature. 2020 Apr;580(7803):402-408. doi: 10.1038/s41586-020-2188-x. Epub 2020 Apr 8.
Nature. 2020.
PMID: 32296183
Free PMC article.
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Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Haenig C, Atias N, Taylor AK, Mazza A, Schaefer MH, Russ J, Riechers SP, Jain S, Coughlin M, Fontaine JF, Freibaum BD, Brusendorf L, Zenkner M, Porras P, Stroedicke M, Schnoegl S, Arnsburg K, Boeddrich A, Pigazzini L, Heutink P, Taylor JP, Kirstein J, Andrade-Navarro MA, Sharan R, Wanker EE.
Haenig C, et al.
Cell Rep. 2020 Aug 18;32(7):108050. doi: 10.1016/j.celrep.2020.108050.
Cell Rep. 2020.
PMID: 32814053
Free article.
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