Three-dimensional tissue fabrication

Adv Drug Deliv Rev. 2004 Sep 22;56(11):1635-47. doi: 10.1016/j.addr.2004.05.001.

Abstract

In recent years, advances in fabrication technologies have brought a new dimension to the field of tissue engineering. Using manufacturing-based methods and hydrogel chemistries, researchers have been able to fabricate tissue engineering scaffolds with complex 3-D architectures and customized chemistries that mimic the in vivo tissue environment. These techniques may be useful in developing therapies for replacing lost tissue function, as in vitro models of living tissue, and also for further enabling fundamental studies of structure/function relationships in three dimensional contexts. Here, we present an overview of 3-D tissue fabrication techniques based on methods for: scaffold fabrication, cellular assembly, and hybrid hydrogel/cell methods and review their potential utility for tissue engineering.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / standards
  • Hydrogels / chemical synthesis
  • Hydrogels / standards
  • Imaging, Three-Dimensional / methods*
  • Imaging, Three-Dimensional / standards
  • Tissue Engineering / methods*
  • Tissue Engineering / standards

Substances

  • Biocompatible Materials
  • Hydrogels