Abstract
We compared the effect of oral administration of taurine (3 g/day) and coenzyme Q10 (CoQ10) (30 mg/day) in 17 patients with congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy, whose ejection fraction assessed by echocardiography was less than 50%. The changes in echocardiographic parameters produced by 6 weeks of treatment were evaluated in a double-blind fashion. In the taurine-treated group significant treatment effect was observed on systolic left ventricular function after 6 weeks. Such an effect was not observed in the CoQ10-treated group.
Publication types
-
Clinical Trial
-
Comparative Study
-
Controlled Clinical Trial
MeSH terms
-
Administration, Oral
-
Cardiomyopathy, Dilated / complications
-
Chronic Disease
-
Coenzymes
-
Coronary Disease / complications
-
Double-Blind Method
-
Drug Evaluation
-
Echocardiography
-
Female
-
Heart Failure / drug therapy*
-
Heart Failure / etiology
-
Heart Failure / physiopathology
-
Humans
-
Male
-
Stroke Volume
-
Taurine / administration & dosage
-
Taurine / therapeutic use*
-
Ubiquinone / analogs & derivatives
-
Ubiquinone / therapeutic use
-
Ventricular Function, Left / drug effects
Substances
-
Coenzymes
-
Ubiquinone
-
Taurine
-
coenzyme Q10