The murine MHC encodes a mammalian homolog of bacterial ribosomal protein S13

Mamm Genome. 1992;2(2):87-95. doi: 10.1007/BF00353855.

Abstract

The mouse major histocompatibility complex (MHC) contains many genes in addition to the classical immune response genes. We have screened overlapping cosmid clones covering 170 kb of the H-2K region for genes expressed in embryonal carcinoma (EC) cells. The Ke-3 gene (Abe et al. 1988) found in this region was further studied by Southern, Northern, and sequence analysis. It is an expressed, intron-containing locus encoding a mouse homolog of the bacterial ribosomal protein S13. This is the first non-organelle S13 homolog identified in metazoans, and its genomic location has been determined precisely.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Blotting, Southern
  • Cloning, Molecular
  • Cosmids
  • DNA
  • Major Histocompatibility Complex / genetics*
  • Mice
  • Molecular Sequence Data
  • Restriction Mapping
  • Ribosomal Proteins / genetics*
  • Sequence Alignment
  • Transcription, Genetic

Substances

  • Ribosomal Proteins
  • DNA

Associated data

  • GENBANK/M76762
  • GENBANK/M76763