Abstract
Signaling through the T cell antigen receptor leading to elimination (negative selection) or differentiation (positive selection) of developing thymocytes generates a self-tolerant T cell repertoire. Here we report that the serine-threonine kinase MINK selectively connects the T cell receptor to a signaling pathway that mediates negative but not positive selection. Analysis of this pathway suggested that the essential function of MINK in the elimination of self-reactive thymocytes may be associated with 'downstream' activation of Jun kinase and enhancement of expression of the proapoptotic molecule Bim.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Down-Regulation
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Potassium Channels, Voltage-Gated / genetics
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Potassium Channels, Voltage-Gated / physiology*
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Receptors, Antigen, T-Cell / immunology*
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Signal Transduction / immunology
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T-Lymphocyte Subsets / cytology
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T-Lymphocyte Subsets / enzymology
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T-Lymphocyte Subsets / immunology*
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T-Lymphocyte Subsets / metabolism
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Thymus Gland / cytology*
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Thymus Gland / enzymology
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Thymus Gland / immunology
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Thymus Gland / metabolism
Substances
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Kcne1 protein, mouse
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Potassium Channels, Voltage-Gated
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Receptors, Antigen, T-Cell