Abstract
The highly polymorphic gene products of the classical MHC class I genes in humans (HLA-A, HLA-B, and HLA-C) play a critical role in the immune defense against intracellular infections. Because non-human primates are important models for AIDS vaccine research, rhesus monkeys from a thoroughly pedigreed and serotyped colony were subjected to full-length cDNA analysis of MHC class I gene transcripts. Rhesus macaques express multiple dominant Mamu-A and Mamu-B transcripts (majors) per chromosome, which are characterized by high expression levels. The presence of additional cDNAs with low levels of expression (minors) suggests evidence for transcriptional control of MHC class I genes. Moreover, phylogenetic analyses illustrate that most of the Mamu-A and Mamu-B loci/lineages identified display no or only limited levels of allelic polymorphism. Thus, MHC class I diversity in rhesus macaques is typified by the existence of an unmatched high number of Mamu-A and Mamu-B region configurations that exhibit polymorphism with regard to the number and combination of transcribed loci present per chromosome.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cloning, Molecular
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HLA-A Antigens / chemistry
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HLA-A Antigens / genetics
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HLA-A Antigens / immunology*
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HLA-B Antigens / chemistry
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HLA-B Antigens / genetics
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HLA-B Antigens / immunology*
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HLA-D Antigens / chemistry
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HLA-D Antigens / genetics
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HLA-D Antigens / immunology*
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Macaca mulatta / classification
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Macaca mulatta / immunology*
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Major Histocompatibility Complex
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Molecular Sequence Data
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Phylogeny
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Polymerase Chain Reaction
Substances
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HLA-A Antigens
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HLA-B Antigens
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HLA-D Antigens
Associated data
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GENBANK/AJ542567
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GENBANK/AJ542568
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GENBANK/AJ542569
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