Abstract
Rab GTPases are key regulators of membrane trafficking in eukaryotes. Recent structural analysis of a number of Rabs, either alone or in complex with partner proteins, has provided new insight into the importance of both conserved and non-conserved features of these proteins that specify their unique functions and localizations. This review will highlight what we have learned from crystallographic analysis of this important protein family.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Motifs
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Amino Acid Sequence
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Conserved Sequence
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Evolution, Molecular
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Humans
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Molecular Sequence Data
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Molecular Structure
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Protein Structure, Tertiary
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Structure-Activity Relationship
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Yeasts / genetics
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Yeasts / physiology
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rab GTP-Binding Proteins / chemistry*
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rab GTP-Binding Proteins / genetics
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rab GTP-Binding Proteins / physiology