Nearly a century after the death of Florence Nightingale (1820-1910), historians continue to debate her legacy. We discuss her seminal work during the Crimean War (1854-1856), the nature of these interventions during the war, and her continued impact today. We argue that Florence Nightingale's influence today extends beyond her undeniable impact on the field of modern nursing to the areas of infection control, hospital epidemiology, and hospice care.