Coevolution of cancer and stromal cellular responses

Cancer Cell. 2005 Jun;7(6):499-500. doi: 10.1016/j.ccr.2005.05.019.

Abstract

It is now becoming apparent that multiple types of stromal cells, including macrophages, mast cells, adipocytes, and fibroblasts make pivotal contributions to carcinogenesis. In the May 6 issue of Cell, Orimo and colleagues (Orimo et al., 2005) show that carcinoma-associated fibroblasts can promote epithelial tumorigenesis by secreting the chemokine SDF-1alpha (CXCL12). SDF-1alpha stimulates carcinoma cell proliferation and recruitment of endothelial precursor cells.

MeSH terms

  • Animals
  • Calcium-Binding Proteins / metabolism
  • Cell Movement
  • Chemokine CXCL12
  • Chemokines, CXC / metabolism
  • Endothelial Cells / cytology
  • Fibroblasts / metabolism
  • Humans
  • Leukocytes / metabolism
  • Matrix Metalloproteinase 9 / metabolism
  • Mesenchymal Stem Cells / cytology
  • Models, Biological
  • Neoplasms / etiology
  • Neoplasms / metabolism*
  • Neovascularization, Pathologic / etiology
  • Neovascularization, Pathologic / metabolism
  • S100 Calcium-Binding Protein A4
  • S100 Proteins
  • Stromal Cells / metabolism*
  • Transforming Growth Factor beta / metabolism
  • Transforming Growth Factor beta / physiology

Substances

  • CXCL12 protein, human
  • Calcium-Binding Proteins
  • Chemokine CXCL12
  • Chemokines, CXC
  • Cxcl12 protein, mouse
  • S100 Calcium-Binding Protein A4
  • S100 Proteins
  • S100a4 protein, mouse
  • Transforming Growth Factor beta
  • Matrix Metalloproteinase 9