Abstract
It is now becoming apparent that multiple types of stromal cells, including macrophages, mast cells, adipocytes, and fibroblasts make pivotal contributions to carcinogenesis. In the May 6 issue of Cell, Orimo and colleagues (Orimo et al., 2005) show that carcinoma-associated fibroblasts can promote epithelial tumorigenesis by secreting the chemokine SDF-1alpha (CXCL12). SDF-1alpha stimulates carcinoma cell proliferation and recruitment of endothelial precursor cells.
MeSH terms
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Animals
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Calcium-Binding Proteins / metabolism
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Cell Movement
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Chemokine CXCL12
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Chemokines, CXC / metabolism
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Endothelial Cells / cytology
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Fibroblasts / metabolism
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Humans
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Leukocytes / metabolism
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Matrix Metalloproteinase 9 / metabolism
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Mesenchymal Stem Cells / cytology
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Models, Biological
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Neoplasms / etiology
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Neoplasms / metabolism*
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Neovascularization, Pathologic / etiology
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Neovascularization, Pathologic / metabolism
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S100 Calcium-Binding Protein A4
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S100 Proteins
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Stromal Cells / metabolism*
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Transforming Growth Factor beta / metabolism
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Transforming Growth Factor beta / physiology
Substances
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CXCL12 protein, human
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Calcium-Binding Proteins
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Chemokine CXCL12
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Chemokines, CXC
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Cxcl12 protein, mouse
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S100 Calcium-Binding Protein A4
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S100 Proteins
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S100a4 protein, mouse
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Transforming Growth Factor beta
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Matrix Metalloproteinase 9