Abstract
Investigation of the EtOAc extract from the Thai sea hare, Bursatella leachii, resulted in the isolation of a potent stimulator of actin assembly, hectochlorin (1), and its new derivative, deacetylhectochlorin (2). Compound 2 exhibited more potent cytotoxicity than 1 against different human carcinoma cell lines. In addition, a new morpholine-2,5-dione analogue, syn-3-isopropyl-6-(4-methoxybenzyl)-4-methylmorpholine-2,5-dione (3), was co-isolated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Aplysia / chemistry*
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Drug Screening Assays, Antitumor
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Humans
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology
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Molecular Structure
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Morpholines / chemistry
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Morpholines / isolation & purification*
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Morpholines / pharmacology
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Thailand
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Thiazoles / chemistry
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Thiazoles / isolation & purification*
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Thiazoles / pharmacology
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Lactones
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Morpholines
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Thiazoles
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hectochlorin