Abstract
Three distinct multiresistant loci from enterobacterial plasmids each comprised an integron and an IS26-associated sequence. Sequence comparison suggested a common ancestral structure that derived from an IS26 insertion into the 5' conserved segment of an In4-type integron and evolved through acquisition of gene cassettes and IS26-mediated recruitment of additional resistance genes of diverse origin.
MeSH terms
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Cloning, Molecular
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DNA Transposable Elements / genetics*
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Drug Resistance, Multiple, Bacterial / genetics*
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Enterobacteriaceae / drug effects
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Enterobacteriaceae / genetics*
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Evolution, Molecular
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Integrons / genetics*
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Molecular Sequence Data
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Plasmids / genetics*
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Polymerase Chain Reaction / methods
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Sequence Analysis, DNA
Substances
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DNA Transposable Elements
Associated data
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GENBANK/AJ009829
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GENBANK/AJ245670
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GENBANK/AY260546
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GENBANK/AY339625
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GENBANK/AY340637