Abstract
We investigated secondary immunity against coccidioidomycosis by using gene expression microarrays. Surprisingly, a high percentage of B-cell-related genes were associated with protective immunity. A functional confirmation of the importance of B cells against coccidioidomycosis was achieved by demonstrating that vaccination was not fully protective in B-cell-deficient MuMT mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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B-Lymphocytes / immunology*
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Coccidioidomycosis / genetics
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Coccidioidomycosis / immunology*
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Coccidioidomycosis / prevention & control
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Female
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Fungal Vaccines / immunology*
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Fungal Vaccines / therapeutic use
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Gene Expression Profiling
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Gene Expression Regulation*
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Genes, Immunoglobulin
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Immunization
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Male
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Mice
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Mice, Mutant Strains
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Oligonucleotide Array Sequence Analysis