Noise in gene expression: origins, consequences, and control

Science. 2005 Sep 23;309(5743):2010-3. doi: 10.1126/science.1105891.

Abstract

Genetically identical cells and organisms exhibit remarkable diversity even when they have identical histories of environmental exposure. Noise, or variation, in the process of gene expression may contribute to this phenotypic variability. Recent studies suggest that this noise has multiple sources, including the stochastic or inherently random nature of the biochemical reactions of gene expression. In this review, we summarize noise terminology and comment on recent investigations into the sources, consequences, and control of noise in gene expression.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alleles
  • Animals
  • Biological Evolution
  • Feedback, Physiological
  • Gene Dosage
  • Gene Expression Regulation
  • Gene Expression*
  • Humans
  • Models, Biological
  • Phenotype*
  • Physiological Phenomena
  • Protein Biosynthesis
  • Proteins / genetics
  • Proteins / metabolism
  • Stochastic Processes
  • Transcription, Genetic

Substances

  • Proteins