Abstract
The hyaloid vascular system (HVS) is a transient network of capillaries that nourishes the embryonic lens and the primary vitreous of the developing eye. We used proteomic analysis and immunohistochemical staining to identify activin receptor-like kinase-1 (ALK1), a type I receptor for transforming growth factor-beta1, during the HVS regression phase. In addition, we overexpressed ALK1 in corneas implanted with bFGF (basic fibroblast growth factor) pellets and observed that ALK1 overexpression resulted in inhibition of bFGF-induced corneal neovascularization in vivo. Our data suggest that ALK1 may play a role in HVS regression during ocular development.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Activin Receptors, Type I / analysis
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Activin Receptors, Type I / genetics
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Activin Receptors, Type I / metabolism*
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Activin Receptors, Type II
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Animals
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Arteries / embryology
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Cornea / blood supply
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Cornea / embryology
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DNA / genetics
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Endothelial Cells / chemistry
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Eye / blood supply*
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Eye / embryology*
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Fibroblast Growth Factors / pharmacology
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Lens, Crystalline / embryology
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Lens, Crystalline / metabolism
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Mice
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Neovascularization, Physiologic* / drug effects
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Neovascularization, Physiologic* / genetics
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Proteomics
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Tunica Intima / cytology
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Vitreous Body / embryology
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Vitreous Body / metabolism
Substances
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Fibroblast Growth Factors
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DNA
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Activin Receptors, Type I
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Activin Receptors, Type II
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Acvrl1 protein, mouse