Abstract
We report the production of poly(lactic-co-glycolic acid) nanoparticles that encapsulate the photosensitizer meso-tetraphenylporpholactol. These nanoparticles are stable and nonphototoxic upon systemic administration. Upon cellular internalization, the photosensitizer is released from the nanoparticle and becomes highly phototoxic. Irradiation with visible light results in cell-specific killing of several cancer cell lines. Importantly, in vivo experiments show complete eradication of cancers in mouse models. The concept of photosensitizers with selective phototoxicity should have widespread applications in cancer therapy.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Proliferation / radiation effects
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Cell Survival / drug effects
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Cell Survival / radiation effects
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Diffusion
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Drug Carriers / administration & dosage*
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Drug Carriers / chemistry*
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Lactic Acid / chemistry
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Male
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Mice
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Nanostructures / chemistry*
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Nanostructures / ultrastructure
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Particle Size
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Photochemotherapy / methods*
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Photosensitizing Agents / administration & dosage*
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Photosensitizing Agents / chemistry*
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Polyglycolic Acid / chemistry
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Polylactic Acid-Polyglycolic Acid Copolymer
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Polymers / chemistry
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Prostatic Neoplasms / drug therapy*
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Prostatic Neoplasms / pathology
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Treatment Outcome
Substances
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Drug Carriers
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Photosensitizing Agents
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Polymers
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Polylactic Acid-Polyglycolic Acid Copolymer
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Polyglycolic Acid
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Lactic Acid