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The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation.
Biochem Biophys Res Commun. 2006 Apr 28;343(1):125-34. doi: 10.1016/j.bbrc.2006.02.125. Epub 2006 Mar 2.
Biochem Biophys Res Commun. 2006.
PMID: 16530727
RELT family members activate p38 and induce apoptosis by a mechanism distinct from TNFR1.
Moua P, Checketts M, Xu LG, Shu HB, Reyland ME, Cusick JK.
Moua P, et al.
Biochem Biophys Res Commun. 2017 Sep 9;491(1):25-32. doi: 10.1016/j.bbrc.2017.07.022. Epub 2017 Jul 5.
Biochem Biophys Res Commun. 2017.
PMID: 28688764
Free PMC article.
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