Abstract
Although diabetes is recognized as a potent and prevalent risk factor for ischemic heart disease, less is known as to whether diabetes causes an altered cardiac phenotype independent of coronary atherosclerosis. Left ventricular systolic and diastolic dysfunction, left ventricular hypertrophy, and alterations in the coronary microcirculation have all been observed, although not consistently, in diabetic cardiomyopathy and are not fully explained by the cellular effects of hyperglycemia alone. The recent recognition that diabetes involves more than abnormal glucose homeostasis provides important new opportunities to examine and understand the impact of complex metabolic disturbances on cardiac structure and function.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cardiomyopathies / etiology*
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Coronary Circulation
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Diabetes Complications / etiology*
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Diabetes Complications / pathology
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Diabetes Complications / physiopathology
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Diabetes Mellitus, Type 1 / complications
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Diabetes Mellitus, Type 2 / complications
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Fatty Acids, Nonesterified / blood
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Humans
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Hyperglycemia / complications
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Hyperinsulinism / complications
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Hypertrophy, Left Ventricular / etiology
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Insulin Resistance
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Phosphatidylinositol 3-Kinases / physiology
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Proto-Oncogene Proteins c-akt / physiology
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Ventricular Dysfunction, Left / etiology
Substances
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Fatty Acids, Nonesterified
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Phosphatidylinositol 3-Kinases
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AKT1 protein, human
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Proto-Oncogene Proteins c-akt