Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4

Cell Death Differ. 2006 Jun;13(6):927-34. doi: 10.1038/sj.cdd.4401912.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Apoptosis
  • Cell Differentiation
  • Cell Proliferation
  • Gene Expression Regulation, Developmental*
  • Humans
  • Mice
  • Mice, Knockout
  • Neurons / cytology
  • Neurons / metabolism
  • Phenotype
  • Promoter Regions, Genetic / genetics
  • Protein Processing, Post-Translational*
  • Proto-Oncogene Proteins / antagonists & inhibitors
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins c-mdm2 / antagonists & inhibitors
  • Proto-Oncogene Proteins c-mdm2 / genetics
  • Proto-Oncogene Proteins c-mdm2 / metabolism*
  • Stem Cells / cytology
  • Stem Cells / metabolism
  • Transcriptional Activation
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism*
  • Ubiquitin / metabolism
  • Ubiquitin-Protein Ligases / antagonists & inhibitors
  • Ubiquitin-Protein Ligases / genetics
  • Ubiquitin-Protein Ligases / metabolism*

Substances

  • Antineoplastic Agents
  • Mdm4 protein, mouse
  • Proto-Oncogene Proteins
  • Tumor Suppressor Protein p53
  • Ubiquitin
  • Mdm2 protein, mouse
  • Proto-Oncogene Proteins c-mdm2
  • Ubiquitin-Protein Ligases