Abstract
Extended-spectrum beta-lactamase (ESBL) production was demonstrated in five independent, multidrug-resistant isolates of enteroaggregative Escherichia coli (EAEC) from the United Arab Emirates, representing 11.3% of the EAEC isolates recovered during 1 year. All five isolates carried the bla(CTX-M-15) and the bla(TEM-1) genes, the former positioned 48 bp downstream of an ISecp1 element. In two isolates, the bla(CTX-M-15 )and bla(TEM-1) genes were located on a 95-kb plasmid. This is the first detailed description and characterisation of ESBL production in enteroaggregative E. coli and also the first report of CTX-M-producing organisms encountered on the Arabian Peninsula.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Child, Preschool
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DNA Primers / chemistry
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DNA, Bacterial / chemistry
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Drug Resistance, Multiple, Bacterial / genetics
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Escherichia coli / drug effects
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Escherichia coli / enzymology
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Escherichia coli / genetics
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Escherichia coli / isolation & purification*
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Escherichia coli Infections / microbiology*
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Feces / microbiology*
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Humans
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Plasmids / genetics
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Polymerase Chain Reaction / methods
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United Arab Emirates
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beta-Lactamases / biosynthesis*
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beta-Lactamases / genetics*
Substances
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DNA Primers
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DNA, Bacterial
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beta-lactamase CTX-M-15
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beta-Lactamases
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beta-lactamase TEM-1