The actin-ADP-ribosylating Clostridium botulinum C2 toxin

Klaus Aktories; Holger Barth

doi:10.1016/j.anaerobe.2003.10.003

The actin-ADP-ribosylating Clostridium botulinum C2 toxin

Anaerobe. 2004 Apr;10(2):101-5. doi: 10.1016/j.anaerobe.2003.10.003.

Authors

Klaus Aktories¹, Holger Barth

Affiliation

¹ Institut für Experimentelle und Klinische, Pharmakologie und Toxikologie, Albert-Ludwigs, Universität Freiburg, Albertstrasse 25, D-79104 Freiburg, Germany. klaus.aktories@pharmakol.uni-freiburg.de

PMID: 16701506
DOI: 10.1016/j.anaerobe.2003.10.003

Abstract

Clostridium botulinum C2 toxin is the prototype of actin-ADP-ribosylating toxins. The toxin consists of the enzyme component C2I and the separated binding/translocation component C2II. C2II is proteolytically activated to form heptamers, which bind the enzyme component. After endocytosis of the receptor-toxin complex, the enzyme component enters the cytosol from an acidic endosomal compartment to modify G-actin at arginine177. Recent data indicate that chaperons are involved in the translocation process of the toxin.