Breaking the (un)sound barrier: filaggrin is a major gene for atopic dermatitis

Alan D Irvine; W H Irwin McLean

doi:10.1038/sj.jid.5700365

Breaking the (un)sound barrier: filaggrin is a major gene for atopic dermatitis

J Invest Dermatol. 2006 Jun;126(6):1200-2. doi: 10.1038/sj.jid.5700365.

Authors

Alan D Irvine¹, W H Irwin McLean

Affiliation

¹ Department of Paediatric Dermatology, Our Lady's Hospital for Sick Children, Crumlin, Dublin, Ireland.

PMID: 16702964
DOI: 10.1038/sj.jid.5700365

Abstract

We have recently shown that loss-of-function mutations in the filaggrin gene, carried by about 10% of people of European ethnicity, cause ichthyosis vulgaris and are strong predisposing factors for atopic dermatitis and asthma secondary to atopic dermatitis. These results demonstrate a prominent role for the epidermal barrier in atopic disease and have important implications for the study of complex traits.

MeSH terms

Child
Dermatitis, Atopic / genetics*
Dermatitis, Atopic / metabolism
Filaggrin Proteins
Genes / genetics
Genetic Predisposition to Disease*
Humans
Intermediate Filament Proteins / analysis
Intermediate Filament Proteins / deficiency*
Intermediate Filament Proteins / genetics*
Mutation
Skin / chemistry
Skin / metabolism*

Substances

FLG protein, human
Filaggrin Proteins
Intermediate Filament Proteins