Abstract
Pseudomonas aeruginosa uses virulence factors controlled by quorum sensing (QS) to kill Caenorhabditis elegans. Here we show that C. elegans is attracted to the acylated homoserine lactones (AHSLs) that mediate QS in P. aeruginosa. Our data also indicate that C. elegans can distinguish AHSLs and may use them to mediate aversive or attractive learning.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Butyrolactone / analogs & derivatives*
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4-Butyrolactone / metabolism
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Animals
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Caenorhabditis elegans / microbiology*
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Caenorhabditis elegans / physiology*
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Chemotaxis*
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Gene Expression Regulation, Bacterial
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Pseudomonas aeruginosa / growth & development
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Pseudomonas aeruginosa / pathogenicity*
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Signal Transduction*
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Virulence
Substances
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Bacterial Proteins
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homoserine lactone
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4-Butyrolactone