Simultaneous biodetoxification of S, N, and O pollutants by engineering of a carbazole-degrading gene cassette in a recombinant biocatalyst

Appl Environ Microbiol. 2006 Nov;72(11):7373-6. doi: 10.1128/AEM.01374-06. Epub 2006 Aug 25.

Abstract

The gene cassette encoding enzymes responsible for degrading carbazole to anthranilic acid was introduced into a dibenzothiophene degrader. The resultant strain, Rhodococcus erythropolis XPDN, could simultaneously transform the model pollutants dibenzothiophene, carbazole, and dibenzofuran to nontoxic metabolites and may have an application potential for bioremediation.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzofurans / chemistry
  • Benzofurans / metabolism*
  • Biodegradation, Environmental
  • Carbazoles / chemistry
  • Carbazoles / metabolism*
  • Environmental Pollutants / chemistry
  • Environmental Pollutants / metabolism*
  • Genetic Engineering / methods*
  • Nitrogen / chemistry
  • Nitrogen / metabolism
  • Oxygen / chemistry
  • Oxygen / metabolism
  • Recombination, Genetic*
  • Rhodococcus / enzymology*
  • Rhodococcus / genetics
  • Rhodococcus / metabolism
  • Sulfur / chemistry
  • Sulfur / metabolism
  • Thiophenes / chemistry
  • Thiophenes / metabolism*

Substances

  • Benzofurans
  • Carbazoles
  • Environmental Pollutants
  • Thiophenes
  • Sulfur
  • dibenzofuran
  • Nitrogen
  • Oxygen
  • dibenzothiophene