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Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2.
Mol Cell Biol. 2006 Nov;26(22):8336-46. doi: 10.1128/MCB.00425-06. Epub 2006 Sep 11.
Mol Cell Biol. 2006.
PMID: 16966370
Free PMC article.
Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy.
Moslehi J, Minamishima YA, Shi J, Neuberg D, Charytan DM, Padera RF, Signoretti S, Liao R, Kaelin WG Jr.
Moslehi J, et al.
Circulation. 2010 Sep 7;122(10):1004-16. doi: 10.1161/CIRCULATIONAHA.109.922427. Epub 2010 Aug 23.
Circulation. 2010.
PMID: 20733101
Free PMC article.
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Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection.
Zhu B, Wu Y, Huang S, Zhang R, Son YM, Li C, Cheon IS, Gao X, Wang M, Chen Y, Zhou X, Nguyen Q, Phan AT, Behl S, Taketo MM, Mack M, Shapiro VS, Zeng H, Ebihara H, Mullon JJ, Edell ES, Reisenauer JS, Demirel N, Kern RM, Chakraborty R, Cui W, Kaplan MH, Zhou X, Goldrath AW, Sun J.
Zhu B, et al.
Immunity. 2021 Jun 8;54(6):1200-1218.e9. doi: 10.1016/j.immuni.2021.04.001. Epub 2021 May 4.
Immunity. 2021.
PMID: 33951416
Free PMC article.
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Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.
Bishop T, Gallagher D, Pascual A, Lygate CA, de Bono JP, Nicholls LG, Ortega-Saenz P, Oster H, Wijeyekoon B, Sutherland AI, Grosfeld A, Aragones J, Schneider M, van Geyte K, Teixeira D, Diez-Juan A, Lopez-Barneo J, Channon KM, Maxwell PH, Pugh CW, Davies AM, Carmeliet P, Ratcliffe PJ.
Bishop T, et al.
Mol Cell Biol. 2008 May;28(10):3386-400. doi: 10.1128/MCB.02041-07. Epub 2008 Mar 10.
Mol Cell Biol. 2008.
PMID: 18332118
Free PMC article.
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Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis.
Laitala A, Aro E, Walkinshaw G, Mäki JM, Rossi M, Heikkilä M, Savolainen ER, Arend M, Kivirikko KI, Koivunen P, Myllyharju J.
Laitala A, et al.
Blood. 2012 Oct 18;120(16):3336-44. doi: 10.1182/blood-2012-07-441824. Epub 2012 Sep 5.
Blood. 2012.
PMID: 22955912
Free article.
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Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR.
Henze AT, Garvalov BK, Seidel S, Cuesta AM, Ritter M, Filatova A, Foss F, Dopeso H, Essmann CL, Maxwell PH, Reifenberger G, Carmeliet P, Acker-Palmer A, Acker T.
Henze AT, et al.
Nat Commun. 2014 Nov 25;5:5582. doi: 10.1038/ncomms6582.
Nat Commun. 2014.
PMID: 25420773
Free PMC article.
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