Intracoronary transplantation of autologous bone marrow mesenchymal stem cells for ischemic cardiomyopathy due to isolated chronic occluded left anterior descending artery

J Invasive Cardiol. 2006 Nov;18(11):552-6.

Abstract

Background: Studies have revealed that stem cells improve clinical outcomes in patients with severe ischemic cardiomyopathy, but the role of bone marrow mesenchymal stem cells is not well understood.

Methods: Twenty-two patients received an implantation of autologous bone marrow mesenchymal stem cell therapy; another 23 patients were placed in a control group after percutaneous coronary intervention (PCI) of the chronically occluded left anterior descending artery.

Results: Reversible defect in the cell therapy group decreased from 16 +/- 8% at baseline to 6 +/- 2% at 12 months (p < 0.05), and this improvement was maintained throughout the entire follow-up period. Compared to the control group (5 +/- 3 METS at baseline vs. 5 +/- 3 METS at 3 months; p = NS), the level of exercise tolerance improved significantly 3 months after cell therapy (5 +/- 2 METS at baseline vs. 7 +/- 3 METS at 3 months; p < 0.05). The NYHA function class also improved in the cell therapy group (2.7 +/- 0.8 at baseline vs. 1.6 +/- 0.1 at 3 months; p < 0.05). PCI alone did not increase left ventricular ejection fraction (LVEF), but following stem cell therapy, the LVEF increased significantly from 26 +/- 6% at baseline to 37 +/- 9% at 3 months (p < 0.05).

Conclusion: Intracoronary transplantation of autologous bone marrow mesenchymal stem cells improved clinical outcomes in patients with chronic ischemic cardiomyopathy.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Angioplasty, Balloon, Coronary / methods*
  • Bone Marrow Transplantation / methods
  • Cardiomyopathies / etiology
  • Cardiomyopathies / mortality
  • Cardiomyopathies / therapy
  • Chronic Disease
  • Combined Modality Therapy
  • Coronary Angiography
  • Coronary Stenosis / complications*
  • Coronary Stenosis / diagnostic imaging
  • Female
  • Follow-Up Studies
  • Humans
  • Injections, Intralesional
  • Male
  • Mesenchymal Stem Cell Transplantation / methods*
  • Middle Aged
  • Myocardial Ischemia / etiology
  • Myocardial Ischemia / mortality
  • Myocardial Ischemia / therapy*
  • Prospective Studies
  • Reference Values
  • Risk Assessment
  • Severity of Illness Index
  • Survival Rate
  • Transplantation, Autologous
  • Treatment Outcome
  • Vascular Patency