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Huntingtin inhibits caspase-3 activation.
Zhang Y, Leavitt BR, van Raamsdonk JM, Dragatsis I, Goldowitz D, MacDonald ME, Hayden MR, Friedlander RM. Zhang Y, et al. EMBO J. 2006 Dec 13;25(24):5896-906. doi: 10.1038/sj.emboj.7601445. Epub 2006 Nov 23. EMBO J. 2006. PMID: 17124493 Free PMC article.
Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity.
Demon D, Van Damme P, Vanden Berghe T, Deceuninck A, Van Durme J, Verspurten J, Helsens K, Impens F, Wejda M, Schymkowitz J, Rousseau F, Madder A, Vandekerckhove J, Declercq W, Gevaert K, Vandenabeele P. Demon D, et al. Mol Cell Proteomics. 2009 Dec;8(12):2700-14. doi: 10.1074/mcp.M900310-MCP200. Epub 2009 Sep 16. Mol Cell Proteomics. 2009. PMID: 19759058 Free PMC article.