Abstract
Adult Cebus apella monkeys were exposed to either one, two or four series of cognitive tasks that place a demand on working memory and inhibitory control (Spatial Delayed Response and Object Retrieval Detour), before administration of the neurotoxin 1-methyl-1-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Following MPTP treatment, monkeys receiving more than one series successfully reached criteria at delays similar to those attained during the pre-MPTP stage for the Spatial Delayed Response task and avoided increased perseveration in the Object Retrieval Detour task. Results provide evidence that protection towards a neurotoxin in specific cognitive performances can be increased by repeated exposure to task-specific cognitive demands and that motor and cognitive impairment following MPTP treatment can be effectively dissociated in primates.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Behavior Therapy / methods*
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Biomarkers / analysis
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Biomarkers / metabolism
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Cebus
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Cognition Disorders / etiology
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Cognition Disorders / prevention & control
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Cognition Disorders / therapy*
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Cognitive Behavioral Therapy / methods*
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Disease Progression
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Dopamine / biosynthesis
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Immunohistochemistry
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Male
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Neuronal Plasticity / physiology
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Neuropsychological Tests / standards*
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Parkinsonian Disorders / complications*
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Parkinsonian Disorders / physiopathology
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Parkinsonian Disorders / psychology*
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Psychomotor Performance / drug effects
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Psychomotor Performance / physiology
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Recovery of Function / physiology
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Substantia Nigra / drug effects
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Substantia Nigra / pathology
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Substantia Nigra / physiopathology
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Tyrosine 3-Monooxygenase / analysis
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Tyrosine 3-Monooxygenase / metabolism
Substances
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Biomarkers
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Tyrosine 3-Monooxygenase
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Dopamine