Abstract
In the large-intestinal mucosae of rats orally administered dextran sulfate sodium, which induces an enteritis resembling ulcerative colitis (UC), the activity for granzyme A, a lymphocyte tryptase, increased at an earlier stage than that at which UC markers (growth-regulated gene product/cytokine-induced neutrophil chemoattractant-1 and caspase-3) increased. This suggests involvement of the enzyme in the exacerbation and perpetuation of enteritis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Caspase 3 / metabolism
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Cells, Cultured
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Chemokine CXCL1
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Chemokines, CXC / metabolism
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Colitis, Ulcerative / chemically induced
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Colitis, Ulcerative / enzymology*
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Dextran Sulfate / pharmacology
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Disease Models, Animal
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Enzyme Activation / drug effects
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Granzymes / metabolism*
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Lymphocytes / drug effects
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Lymphocytes / enzymology
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Male
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Rats
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Rats, Sprague-Dawley
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Tryptases / metabolism*
Substances
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Chemokine CXCL1
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Chemokines, CXC
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Cxcl1 protein, rat
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Dextran Sulfate
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Granzymes
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Tryptases
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Caspase 3