First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase

Maria Virginia Villegas; Karen Lolans; Adriana Correa; Juan Nicolas Kattan; Jaime A Lopez; John P Quinn; Colombian Nosocomial Resistance Study Group

doi:10.1128/AAC.01405-06

First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase

Antimicrob Agents Chemother. 2007 Apr;51(4):1553-5. doi: 10.1128/AAC.01405-06. Epub 2007 Jan 29.

Authors

Maria Virginia Villegas¹, Karen Lolans, Adriana Correa, Juan Nicolas Kattan, Jaime A Lopez, John P Quinn; Colombian Nosocomial Resistance Study Group

Affiliation

¹ CIDEIM, International Center for Medical Research and Training, Cali, Colombia.

Abstract

In Medellin, Colombia, three Pseudomonas aeruginosa isolates with high-level carbapenem resistance (MIC>or=256 microg/ml) and an isolate of Citrobacter freundii with reduced susceptibility to imipenem produced the plasmid-mediated class A carbapenemase KPC-2. This is the first report of a KPC-type beta-lactamase identified outside of the family Enterobacteriaceae.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbapenems / metabolism
Carbapenems / pharmacology
Drug Resistance, Bacterial / genetics*
Hydrolysis
Microbial Sensitivity Tests
Pseudomonas aeruginosa / enzymology*
Pseudomonas aeruginosa / genetics
beta-Lactamases / genetics
beta-Lactamases / metabolism*

Substances

Carbapenems
beta-lactamase KPC-1
beta-Lactamases