Abstract
The elongation factor 1- and elongation factor 2-dependent GTPase (guanosine triphosphatase) activities of ribosomes are inhibited by ricin, a toxic protein known to inactivate the 60S ribosomal subunit. It is suggested that also in eukaryotic ribosomes a "GTPase site', located on the larger subunit, is common to the two elongation factors.
MeSH terms
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Animals
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Depression, Chemical
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GTP Phosphohydrolase-Linked Elongation Factors / antagonists & inhibitors
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GTP Phosphohydrolase-Linked Elongation Factors / metabolism*
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In Vitro Techniques
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Kinetics
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Peptide Elongation Factors*
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Phenylalanine
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Phosphoric Monoester Hydrolases / metabolism*
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Plant Proteins / pharmacology*
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RNA, Transfer
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Rats
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Ribosomes / drug effects*
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Ribosomes / metabolism
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Ricin / pharmacology*
Substances
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Peptide Elongation Factors
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Plant Proteins
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Phenylalanine
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Ricin
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RNA, Transfer
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Phosphoric Monoester Hydrolases
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GTP Phosphohydrolase-Linked Elongation Factors