Abstract
We amplified gag sequences from 66 individuals infected with HIV-1 CRF07_BC during 2003-2005 in the Xinjiang region of China. A novel deletion of 7aa (including a KELY motif) in the central region of the CRF07_BC gag p6 domain was detected, which has not been reported in other HIV-1 subtypes. Further deletions of up to 13aa (including KQE and KELY motifs) was also found in this domain, representing the biggest natural deletion up to now. Moreover, the CD4+ count and viral load level indicated that 1-13aa deletions in CRF07_BC gag p6 do not have a significant effect on viral replication and fitness.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Gene Products, gag / chemistry
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Gene Products, gag / genetics*
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Genes, gag
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HIV Infections / virology
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HIV-1 / classification*
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HIV-1 / genetics*
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Humans
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Molecular Sequence Data
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Phylogeny
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Polymerase Chain Reaction
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Recombination, Genetic*
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Sequence Alignment
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Sequence Analysis, DNA
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Sequence Deletion*
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Substance Abuse, Intravenous / complications
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gag Gene Products, Human Immunodeficiency Virus
Substances
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Gene Products, gag
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gag Gene Products, Human Immunodeficiency Virus
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p6 gag protein, Human immunodeficiency virus 1