Abstract
The interferons (IFNs) and their receptors represent a subset of the class 2 alpha-helical cytokines that have been in chordates for millions of years. This brief review focuses on the discovery and purification of interferons, cloning of human IFN-alpha and IFN-beta, interferon receptors, activities and therapeutic uses of interferons, and the side effects of interferons.
Publication types
-
Historical Article
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Biological Evolution
-
History, 20th Century
-
History, 21st Century
-
Humans
-
Interferons / adverse effects
-
Interferons / history
-
Interferons / physiology*
-
Interferons / therapeutic use
-
Receptor, Interferon alpha-beta / history
-
Receptor, Interferon alpha-beta / physiology*
Substances
-
Receptor, Interferon alpha-beta
-
Interferons