Abstract
We identify ef1090 (renamed ebpR) and show its importance for the transcriptional regulation of expression of the Enterococcus faecalis pilus operon, ebpABC. An ebpR deletion (DeltaebpR) mutant was found to have reduced ebpABC expression with loss of pilus production and a defect in primary adherence with, as a consequence, reduced biofilm formation.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Adhesion / genetics
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Bacterial Adhesion / physiology
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Bacterial Proteins / genetics
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Bacterial Proteins / physiology*
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Biofilms / growth & development*
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Enterococcus faecalis / genetics
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Enterococcus faecalis / physiology*
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Fimbriae, Bacterial / genetics*
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Gene Deletion
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Gene Expression Regulation, Bacterial*
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Operon*
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Transcription Factors / genetics
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Transcription Factors / physiology*
Substances
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Bacterial Proteins
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Transcription Factors