Abstract
The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act together in responding cells to integrate intercellular Hedgehog (Hh) and other signaling inputs, resulting in the regulation of tissue pattern, size and shape. Hh and other inputs are then just ways to modify the Gli code. Recent data confirm this idea and suggest that the Gli code regulates stemness and also tumor progression and metastatic growth, opening exciting possibilities for both regenerative medicine and novel anticancer therapies.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Body Patterning*
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Cell Differentiation / physiology
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Cellular Senescence
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Disease Progression
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Gene Expression Regulation, Developmental
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Hedgehog Proteins / metabolism*
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Humans
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Neoplasm Metastasis
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Neoplasms* / metabolism
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Neoplasms* / pathology
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Neoplasms* / physiopathology
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Neoplasms* / therapy
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Oncogene Proteins / genetics
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Oncogene Proteins / metabolism*
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Oncogenes
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Signal Transduction / physiology*
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Stem Cells / cytology
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Stem Cells / physiology*
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Trans-Activators / genetics
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Trans-Activators / metabolism*
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Zinc Finger Protein GLI1
Substances
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Hedgehog Proteins
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Oncogene Proteins
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Trans-Activators
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Zinc Finger Protein GLI1