Abstract
Beta-catenin plays a critical structural role in cadherin-based adhesions and is also an essential co-activator of Wnt-mediated gene expression. The degree to which beta-catenin participates in these two functions is dictated by the availability of beta-catenin binding partners, and an emerging theme is that these binding interactions are regulated by phosphorylation. Inputs from various cell-signaling events can therefore impact beta-catenin function, which may be necessary for the finely tuned adhesive and signaling responses required for tissue morphogenesis.
MeSH terms
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Animals
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Cadherins / chemistry
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Cadherins / metabolism*
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Cell Adhesion / physiology*
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / metabolism
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Gene Expression Regulation
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Humans
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Phosphorylation
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Protein Binding
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Protein Interaction Domains and Motifs / physiology
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Signal Transduction
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Trans-Activators / chemistry
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Trans-Activators / metabolism
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Wnt Proteins / chemistry
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Wnt Proteins / genetics
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Wnt Proteins / metabolism*
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beta Catenin* / chemistry
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beta Catenin* / genetics
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beta Catenin* / metabolism
Substances
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Cadherins
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DNA-Binding Proteins
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Trans-Activators
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Wnt Proteins
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beta Catenin