Abstract
Enterotoxigenic Escherichia coli (ETEC) strains produce a type IV pilus named Longus. We identified a 16-gene cluster involved in the biosynthesis of Longus that has 57 to 95% identity at the protein level to CFA/III, another type IV pilus of ETEC. Alleles of the Longus structural subunit gene lngA demonstrate a diversity of 12 to 19% at the protein level with strong positive selection for point replacements and horizontal transfer.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Toxins / genetics
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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Enterotoxigenic Escherichia coli / genetics*
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Escherichia coli Proteins / genetics
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Fimbriae, Bacterial / genetics*
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Genetic Variation*
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Molecular Sequence Data
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Multigene Family*
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
Substances
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Bacterial Toxins
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DNA, Bacterial
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Escherichia coli Proteins
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LngA protein, E coli
Associated data
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GENBANK/EF595770
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GENBANK/EU107087
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GENBANK/EU107088
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GENBANK/EU107089
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GENBANK/EU107090
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GENBANK/EU107091
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GENBANK/EU107092
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GENBANK/EU107093
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GENBANK/EU107094
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GENBANK/EU107095
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GENBANK/EU107096
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GENBANK/EU107097
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GENBANK/EU107098
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GENBANK/EU107099
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GENBANK/EU107100
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GENBANK/EU107101
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GENBANK/EU107102
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GENBANK/EU107103
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GENBANK/EU107104
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GENBANK/EU107105
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GENBANK/EU107106
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GENBANK/EU107107