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Increased microvascular permeability in mice lacking Epac1 (Rapgef3).
Kopperud RK, Rygh CB, Karlsen TV, Krakstad C, Kleppe R, Hoivik EA, Bakke M, Tenstad O, Selheim F, Lidén Å, Madsen L, Pavlin T, Taxt T, Kristiansen K, Curry FE, Reed RK, Døskeland SO. Kopperud RK, et al. Acta Physiol (Oxf). 2017 Feb;219(2):441-452. doi: 10.1111/apha.12697. Epub 2016 May 17. Acta Physiol (Oxf). 2017. PMID: 27096875 Free PMC article.
Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses.
Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y. Okumura S, et al. J Clin Invest. 2014 Jun;124(6):2785-801. doi: 10.1172/JCI64784. Epub 2014 Apr 24. J Clin Invest. 2014. PMID: 24892712 Free PMC article.