Abstract
To initiate infection, poliovirus must release its RNA genome into the cytoplasm of a target cell, a process called 'uncoating'. How this occurs has remained uncertain, despite studies over several decades. Two new studies re-address the question of poliovirus entry. The results suggest that poliovirus enters different cells by different mechanisms, and point to a role for virus-induced intracellular signals in the process.
MeSH terms
-
Caveolae / virology
-
Clathrin-Coated Vesicles / virology
-
Cytoplasm / virology
-
Endocytosis
-
Endothelial Cells / virology
-
Fluorescent Dyes / metabolism*
-
HeLa Cells
-
Humans
-
Membrane Proteins / metabolism
-
Microscopy, Fluorescence
-
Poliovirus / physiology*
-
Poliovirus / ultrastructure
-
RNA, Viral / metabolism
-
Receptors, Virus / metabolism
-
Staining and Labeling
-
Virion / metabolism
-
Virus Internalization*
Substances
-
Fluorescent Dyes
-
Membrane Proteins
-
RNA, Viral
-
Receptors, Virus
-
poliovirus receptor