Abstract
The 66 KDa isoform of Shc and its signalling properties have attracted in the past years major interest in aging research. Here, we summarize p66Shc functions and outline a specific signalling route leading to mitochondrial import, that accounts for its pro-apoptotic activity upon oxidative stress. This model, that could explain the alterations of mitochondrial Ca2+ homeostasis observed after oxidative stress, highlights novel pharmacological targets in age-related disorders.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics
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Adaptor Proteins, Signal Transducing / metabolism*
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Adaptor Proteins, Signal Transducing / physiology
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Aging / genetics
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Aging / metabolism*
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Animals
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Cellular Senescence / genetics
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Cellular Senescence / physiology
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Humans
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Longevity / genetics
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Longevity / physiology*
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Mitochondria / genetics
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Mitochondria / metabolism*
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Oxidative Stress / genetics
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Oxidative Stress / physiology*
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Protein Transport / genetics
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Protein Transport / physiology
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Reactive Oxygen Species / metabolism
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Shc Signaling Adaptor Proteins
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Src Homology 2 Domain-Containing, Transforming Protein 1
Substances
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Adaptor Proteins, Signal Transducing
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Reactive Oxygen Species
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SHC1 protein, human
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Shc Signaling Adaptor Proteins
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Src Homology 2 Domain-Containing, Transforming Protein 1