Autoimmune myelopathy associated with collapsin response-mediator protein-5 immunoglobulin G

Ann Neurol. 2008 Apr;63(4):531-4. doi: 10.1002/ana.21324.

Abstract

Several autoimmune myelopathies are recognized clinically. We describe 57 patients in whom serological evaluation for myelopathy of uncertain cause demonstrated collapsin response-mediator protein 5 IgG. Most had spinal imaging and cerebrospinal fluid abnormalities and insidiously progressive presentation; some had acute monophasic or relapsing myelopathy. Initial diagnoses included multiple sclerosis, transverse myelitis, and unspecified neurodegenerative myelopathy. Most were smokers; neoplasia was discovered in 68% (most commonly small-cell lung carcinoma and after collapsin response-mediator protein-5 IgG detection). Collapsin response-mediator protein-5 autoimmune myelopathy and occult neoplasia are important considerations in patients with insidiously progressive myelopathy, especially with known cancer risk.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Autoantibodies / biosynthesis*
  • Autoantibodies / blood
  • Autoantibodies / cerebrospinal fluid
  • Cohort Studies
  • Diagnosis, Differential
  • Disease Progression
  • Female
  • Humans
  • Hydrolases
  • Immunoglobulin G / biosynthesis*
  • Immunoglobulin G / blood
  • Immunoglobulin G / cerebrospinal fluid
  • Male
  • Microtubule-Associated Proteins
  • Middle Aged
  • Neoplasms / complications
  • Neoplasms / diagnosis
  • Neoplasms / immunology
  • Neoplasms / pathology
  • Nerve Tissue Proteins / immunology*
  • Spinal Cord Diseases / complications*
  • Spinal Cord Diseases / diagnosis
  • Spinal Cord Diseases / immunology*
  • Spinal Cord Diseases / pathology

Substances

  • Autoantibodies
  • Immunoglobulin G
  • Microtubule-Associated Proteins
  • Nerve Tissue Proteins
  • DPYSL5 protein, human
  • Hydrolases