Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

Nat Genet. 2008 Jun;40(6):713-5. doi: 10.1038/ng.148. Epub 2008 Apr 27.

Abstract

Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we investigated 50 previously reported susceptibility loci in a German sample of individuals with Crohn's disease (n = 1,850) or ulcerative colitis (n = 1,103) and healthy controls (n = 1,817). Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / metabolism*
  • Case-Control Studies
  • Chromosomes, Human, Pair 3 / genetics*
  • Cohort Studies
  • Colitis, Ulcerative / epidemiology
  • Colitis, Ulcerative / genetics*
  • Crohn Disease / epidemiology
  • Crohn Disease / genetics*
  • Female
  • Genetic Predisposition to Disease*
  • Genetic Variation*
  • Guanine Nucleotide Exchange Factors / genetics
  • Homeodomain Proteins / genetics
  • Humans
  • Male
  • Polymorphism, Single Nucleotide / genetics*
  • Protein Tyrosine Phosphatase, Non-Receptor Type 2 / genetics
  • Risk Factors
  • STAT3 Transcription Factor / genetics
  • Ubiquitin-Protein Ligases

Substances

  • Biomarkers
  • Guanine Nucleotide Exchange Factors
  • Homeodomain Proteins
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • HERC2 protein, human
  • Ubiquitin-Protein Ligases
  • PTPN2 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 2