Autophagy-modulating aminosteroids isolated from the sponge Cliona celata

Org Lett. 2008 Jul 17;10(14):2959-62. doi: 10.1021/ol800937u. Epub 2008 Jun 14.

Abstract

Clionamines A-D (1- 4), new aminosteroids that modulate autophagy, have been isolated from South African specimens of the sponge Cliona celata. Clionamine D (4) has an unprecedented spiro bislactone side chain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Marine Biology
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Porifera / chemistry*
  • Spiro Compounds / chemical synthesis*
  • Spiro Compounds / chemistry
  • Steroids / chemical synthesis*
  • Steroids / chemistry

Substances

  • Spiro Compounds
  • Steroids
  • clionamine D