What is the contents of the magic draft IVIg?

Jean-François Seite; Yehuda Shoenfeld; Pierre Youinou; Sophie Hillion

doi:10.1016/j.autrev.2008.04.012

What is the contents of the magic draft IVIg?

Autoimmun Rev. 2008 Jun;7(6):435-9. doi: 10.1016/j.autrev.2008.04.012. Epub 2008 May 2.

Authors

Jean-François Seite¹, Yehuda Shoenfeld, Pierre Youinou, Sophie Hillion

Affiliation

¹ Immunology and Pathology Research Unit, Medical School, Brest, France.

PMID: 18558358
DOI: 10.1016/j.autrev.2008.04.012

Abstract

Intravenous immunoglobulins (IVIg) consist of IgG concentrated from pooled plasma of numerous donors. Their contents is variable, depending in part on the method of preparation. Natural antibodies and natural autoantibodies are prominent in these preparations and their function. Among these, are the idiotype (Id)/anti-Id dimers. Attention has recently been paid to Fc-gamma receptors and sialylation of the IgG from IVIg.

Publication types

Review

MeSH terms

Autoantibodies / blood
Autoantibodies / immunology*
Humans
Immunoglobulin Fc Fragments / metabolism
Immunoglobulin G / blood
Immunoglobulin G / immunology
Immunoglobulin Idiotypes / immunology
Immunoglobulins, Intravenous / blood
Immunoglobulins, Intravenous / immunology*
Immunoglobulins, Intravenous / metabolism
Receptors, IgG / metabolism

Substances

Autoantibodies
Immunoglobulin Fc Fragments
Immunoglobulin G
Immunoglobulin Idiotypes
Immunoglobulins, Intravenous
Receptors, IgG