Abstract
G protein-coupled receptor kinase-interactor 2 (GIT2) is a signaling scaffold protein that also functions as GTPase-activating protein (GAPs) for ADP-ribosylation factor (Arf) small GTP-binding proteins. GIT2 has been implicated in the regulation of G protein-coupled receptor trafficking and cell adhesion and migration. To evaluate possible neurobehavioral functions of GIT2 in vivo, we evaluated GIT2-knockout (KO) mice for abnormalities in emotionality and mood. Male and female GIT2-KO mice presented with anxiety-like behaviors in the zero-maze and light-dark emergence tests. Immobility times in tail suspension were reduced in GIT2-KO males, but were normal in GIT2-KO females. Hence, GIT2-KO mice display anxiety-like behavior in an absence of depressive-like responses.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anxiety Disorders / genetics*
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Anxiety Disorders / metabolism*
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Anxiety Disorders / physiopathology
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Brain / metabolism*
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Brain / physiopathology
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Brain Chemistry / genetics*
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Cell Cycle Proteins / genetics*
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Depressive Disorder / genetics
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Depressive Disorder / metabolism
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Depressive Disorder / physiopathology
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Disease Models, Animal
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Female
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GTPase-Activating Proteins
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Intercellular Signaling Peptides and Proteins
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Male
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Maze Learning / physiology
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Mice
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Mice, Knockout
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Neuropsychological Tests
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Phosphoproteins / genetics*
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Sex Characteristics
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Signal Transduction / genetics
Substances
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Cell Cycle Proteins
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GTPase-Activating Proteins
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Git2 protein, mouse
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Intercellular Signaling Peptides and Proteins
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Phosphoproteins