Abstract
Adult T-cell leukemia (ATL) is an aggressive disease characterized by visceral invasion, and ATL regulates matrix metalloproteinase (MMP) activities of the endothelial cells. The controlling system of MMP activities in ATL is regulated by various factors such as Emmprin and tissue inhibitor of MMP. In this study, we demonstrated that Testican 3 expression in ATL decreased the activity of MMP. Furthermore, we showed that the expression of Testican 3 was regulated by activating transcriptional factor 3 in human T-lymphotropic virus type I-related cell lines. Thus, Testican 3 is a novel regulator to reduce the activity of MMP in ATL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Activating Transcription Factor 3 / genetics
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Activating Transcription Factor 3 / metabolism*
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Adult
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Anisomycin / pharmacology
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Blotting, Western
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Cell Line, Transformed
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Human T-lymphotropic virus 1 / genetics
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Humans
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Leukemia-Lymphoma, Adult T-Cell / genetics*
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Leukemia-Lymphoma, Adult T-Cell / metabolism
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Leukemia-Lymphoma, Adult T-Cell / pathology
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Matrix Metalloproteinase 2 / metabolism
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Matrix Metalloproteinase 9 / metabolism
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Matrix Metalloproteinase Inhibitors*
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Protein Synthesis Inhibitors / pharmacology
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Proteoglycans / genetics*
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Proteoglycans / metabolism
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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RNA, Small Interfering / pharmacology
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Reverse Transcriptase Polymerase Chain Reaction
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Tumor Cells, Cultured
Substances
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ATF3 protein, human
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Activating Transcription Factor 3
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Matrix Metalloproteinase Inhibitors
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Protein Synthesis Inhibitors
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Proteoglycans
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RNA, Messenger
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RNA, Small Interfering
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SPOCK3 protein, human
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Anisomycin
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Matrix Metalloproteinase 2
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Matrix Metalloproteinase 9