Abstract
We evaluated the in vivo anti-inflammatory and analgesic activities of orally administered paeonol in mice, and also investigated the anti-inflammatory activity of paeonol in a cell line. Paeonol significantly reduced the edema induced by arachidonic acid in rats. The analgesic effects were assayed using 2 different models, i.e., by acetic acid-induced writhing response and by formalin induced licking and biting time. Moreover, we examined the effects of paeonol on the release of inflammatory mediators such as NO, PGE(2) and IL-6. Our results demonstrated that paeonol inhibited LPS induced expression of NO, PGE(2) and IL-6. Paeonol prevented LPS induced iNOS, COX-2 and ERK activation. Therefore, paeonol appears to have potential as a treatment for inflammatory disease and analgesic.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetophenones / pharmacology*
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Acetophenones / therapeutic use
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Analgesics / pharmacology*
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Analgesics / therapeutic use
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Animals
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Anti-Inflammatory Agents / pharmacology*
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Cell Survival
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Cyclooxygenase 2 / metabolism
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Cynanchum*
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Dinoprostone / metabolism
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Edema / chemically induced
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Edema / drug therapy
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Interleukin-6 / metabolism
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Lipopolysaccharides
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Male
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Mice
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Mice, Inbred ICR
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Mitogen-Activated Protein Kinases / antagonists & inhibitors*
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Nitric Oxide / metabolism
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Nitric Oxide Synthase Type II / metabolism
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Pain / drug therapy
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Phytotherapy
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Plant Extracts / pharmacology*
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Plant Roots
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Rats
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Rats, Sprague-Dawley
Substances
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Acetophenones
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Analgesics
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Anti-Inflammatory Agents
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Interleukin-6
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Lipopolysaccharides
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Plant Extracts
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Nitric Oxide
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paeonol
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Nitric Oxide Synthase Type II
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Cyclooxygenase 2
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Mitogen-Activated Protein Kinases
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Dinoprostone