Abstract
The results demonstrate that the HMG I protein is expressed in human quiescent T lymphocytes and hence is not dependent upon proliferation or neoplastic transformation. Furthermore it has been found that the HMG I/histone H1 ratio increase about two-fold after activation with phytohemagglutinin and was about the same as in a number of proliferating human leukemia lymphoma T-cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Monoclonal
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Blotting, Western
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Cell Division
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Cell Line
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Cell Transformation, Neoplastic / genetics*
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Electrophoresis, Polyacrylamide Gel
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High Mobility Group Proteins / biosynthesis*
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High Mobility Group Proteins / genetics
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High Mobility Group Proteins / isolation & purification
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High Mobility Group Proteins / metabolism
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Histones / metabolism
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Humans
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Leukemia-Lymphoma, Adult T-Cell
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T-Lymphocytes / cytology
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T-Lymphocytes / metabolism*
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Tumor Cells, Cultured
Substances
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Antibodies, Monoclonal
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High Mobility Group Proteins
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Histones