Porphyromonas gingivalis-host interactions: open war or intelligent guerilla tactics?

Microbes Infect. 2009 May-Jun;11(6-7):637-45. doi: 10.1016/j.micinf.2009.03.009. Epub 2009 Apr 5.

Abstract

This review summarizes and discusses virulence mechanisms whereby Porphyromonas gingivalis can persist in the oral cavity. It is proposed that the virulence of P. gingivalis is dependent, at least in part, upon its ability to establish a complex host-pathogen molecular crosstalk which subverts innate immunity. The sophisticated stealth and sabotage tactics used by P. gingivalis may additionally benefit co-habiting organisms occupying the same niche.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Bacteroidaceae Infections / immunology*
  • Bacteroidaceae Infections / microbiology*
  • Host-Pathogen Interactions*
  • Humans
  • Models, Biological
  • Mouth / microbiology
  • Porphyromonas gingivalis / immunology*
  • Porphyromonas gingivalis / pathogenicity*
  • Virulence